A SINGLE INSTITUTION RETROSPECTIVE REVIEW OF RADICAL RADIOTHERAPY OUTCOMES FOR CANCER OF THE OESOPHAGUS REPORTS ZERO TOXICITY.
A single institution retrospective review of radical radiotherapy outcomes for cancer of the oesophagus reports zero toxicity. Discuss the implications of this statement from a RADIOBIOLOGICAL VIEWPOINT, with particular reference to tumour control. 2. How do early and late radiation reactions differ with respect to latency, rates of evolution once established, fractionation sensitivity and the effects of overall treatment time? List and define reaction scoring systems in common clinical use and give one example of how they rank an early and a late reaction. How are dose-response data for these endpoints plotted on graphs? 3. Discuss the RADIOBIOLOGICAL RATIONALE for pre-, post- and intra-operative radiation therapy. 4. How would you describe the underlying principles of CHART to an interested medical colleague? Can you suggest how the CHART schedule might be modified to make it more generally applicable? 5. Write short notes on three of the following: a. Stochastic effects of ionising radiation b. Tumour suppressor genes c. Western blotting d. The CDK-cyclin complex
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