Antithrombotic guideline contains more than 600 recommendations meant for diagnosis, prevention, and treatment of thrombosis.

Antithrombotic guideline contains more than 600 recommendations meant for diagnosis, prevention, and treatment of thrombosis.

It also gives guidelines on stroke, children clinical conditions, surgery, atrial fibrillation, orthopedic surgery, pregnancy, and cardiovascular diseases (Irwin, 2012). AT9 guidelines show the current science evidence-based clinical practice guideline development.

Consider the antithrombotic therapy in infants and children show several guidelines and recommendations on following specific target ranges for both un-fractioned and low-molecular-weight heparins in children and neonates. It encourages clinical trials that exhibit different pharmacokinetics, monitoring tests, and dose responses for anticoagulation therapy in children in comparison to the adults (Lugassy, 2000).

The history of the current clinical guidelines can be traced back to 2001 when ACCP Consensus Conference on Antithrombotic therapy (AT6) was published on 2001. They adopted an approach of rating quality of evidence and strength of recommendations. Since then there have been improvements over the years; we had AT7, AT8 and now At9. At9 includes improvements from AT8 and involves the evolution of the systematic science reviews and clinical practical guidelines (Irwin, 2012).

The antithrombotic therapy guideline has many limitations as the authors failed to give a table of evidence profiles and summary of the findings. This recommendation used only evidence-based systematic review and assessment on relevant studies; it never used meta-analysis to clarify the evidence. The guideline will be in use after thorough review and updating.

The recommendation if followed may be hazardous to the children with multiple diseases. For example, the patient may be cancerous and therefore their recommendations cannot be appropriate. Therefore, the proper way to prove the recommendations right is to conduct a meta-analysis on various fields of recommendations. The patient should be investigated through recommended tests to establish the causal agents of the problem. Factors such as environment, sex of the patient, age , and socio-economic life of the patient.


 

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